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A significant focus was on developing inhibitors of insulin-regulated aminopeptidase (IRAP), a protein identified as the AT4 receptor, with the goal of enhancing metabolic stability and BBB permeability

It is built strictly as an informational comparison, not a shopping guide or a ranking by price, since none of these compounds are FDA-approved consumer products sold at a fixed retail cost

Orforglipron significantly reduced HbA1c to 2.1% in a phase II clinical trial assessing its use in T2DM, while dulaglutide achieved 1.1% and a placebo achieved 0.43% [106]

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