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Critical markers during combined use IGF-1 levels: Check every 4 weeks for the first 12 weeks, then every 8 weeks if stable

Diuretics or water-pills like furosemide and hydrochlorothiazide may also be prescribed as they work to prevent or treat fluid accumulation in the body

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Genes in this locus have high evolutionarily conserved sequences and paralogous in several other loci (for instances, Chr 11qB(1.3) (Irgm2, Igtp), Chr18 (Iigp1, F830016B08Rik)), in other chromosomes and orthologous in genomes of many species ( Figure 8A , Supplementary Figure S4)