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Nicotine aerosol inhalation induces acute cardiac arrhythmia where sinoatrial (SA) block, sinus arrest, atrioventricular (A-V) block and supraventricular escape rhythm were demonstrated by ECG analysis in rats suggesting a disturbance of parasympathetic and sympathetic cardiac control mediated by the nAChRs (192)

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Nicotine triggers the stimulation of the central nervous system and the release of the excitatory hormone adrenaline