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The coverage guidelines are as follows: Pemetrexed: One intramuscular injection of vitamin B12 before the first dose and then every three cycles

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[3] Side effects [edit] Some side effects for peptide hormones and analogues are motor paralysis, diabetes mellitus, hypothyroidism, headaches, vomiting, thrombosis, osteoporosis, and cancer

Although the FAERS database aids in detecting rare adverse events via spontaneous reporting, its propensity to overestimate unexpected adverse events linked to new therapies makes it inappropriate for comparative analysis of adverse event frequencies among pharmaceuticals