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[60] reported a significant downregulation of CD4 + CD25 + Treg cells in BAL fluid of patients with COPD compared with healthy smokers

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Because of the ability of this curing method to "fix" sugars (maintain the sugars in a relatively stable percentage), a form of flue curing is used in making candela (green) cigar wrapper, as the heat not only fixes the sugars (which are fairly low in cigar leaf) but the chlorophyll as well, allowing the wrappers to stay green