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In 2010, 22 billion untaxed cigarettes were smoked in Germany, according to the Deutscher Zigarettenverband (DZV), a German tobacco lobby

Consistently, in Gpr15 +/+ mice, prolonged cigarette smoke exposure in the TNBS model led to aggravated colitis, as reflected by greater weight loss, elevated DAI, colon shortening, and worsened histological and endoscopic scores, accompanied by increased Gpr15 expression (Supplementary Fig