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Alcohol: Date this section was last reviewed 22/07/2013 (PL) Drug misuse: Headlines Misuse of drugs is strongly associated with a range of physical and mental health problems such as blood borne viruses including hepatitis B and C and is strongly associated with a range of social issues including school absenteeism, safeguarding, troubled families, homelessness and unemployment

We propose that cigarette smoking impairs immunosuppressive function of Tregs by reducing the number of suppressive Tregs or increasing the prevalence of non-suppressive Tregs, leading to an enhanced autoimmune component in COPD pathogenesis, while increased Treg numbers may occur in some smokers under circumstances, leading to worsened respiratory infections

J Cell Physiol 160(1):154162 Karbach S et al (2014) eNOS uncoupling in cardiovascular diseases--the role of oxidative stress and inflammation