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There are superscripted numbers 1, 2, and 3 associated with drug use disorder, opioid use disorder, and central nervous system stimulant use disorder, respectively, to direct readers to the text for footnotes 1, 2, and 3

"These declines also underscore the proven effectiveness of strategies that have been implemented to reduce tobacco use, including increased tobacco taxes and prices, comprehensive smoke-free laws, well-funded prevention and cessation programs, hard-hitting mass media campaigns, and, more recently, state and local laws ending the sale of flavored tobacco products," he said

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Compare that to the smoking of a single high-nicotine cigarette which increased the resting measurement of systolic blood pressure times heart rate by 36%, also increased the venous carboxyhemoglobin level, and decreased the exercise time until angina by 23%