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Yet thousands of smokers roll pipe tobacco every day, and the practice has created an entire gray market that regulators have been scrambling to address

May 24, 2023 Main photo credit: Buletin Sabah

If such mutations are seen in critical regions of important growth control genes, the end-result may be the loss of normal cellular growth control mechanisms, genomic instability, as well as cancer in the long run

Depending on the direction of effect reported in the majority of the studies, we concluded that there were no significant age or sex-based differences in the risk of any cancer following e-cigarette exposure (Figure 4)