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Microenvironmental effects need to be systematically evaluated: previous studies have shown that ACE induces apoptosis by inhibiting HIF-1, 51 , so whether hypoxia regulates ACE sensitivity through HIF-1 signaling deserves further investigation

Research shows promising results for DSIPs effectiveness and safety

Furthermore, it is important to note that IV glutathione lacks FDA approval specifically for skin whitening, and the long-term safety of high-dose injections is still not fully understood

Although this may offer systemic recovery and healing benefits, it introduces complexity in predicting responsesespecially in polypharmacy and comorbidity contexts