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Vitamin B12 is a water-soluble vitamin that plays a crucial role in various bodily processes, including energy production and nerve function

1 g/mL doxycycline (Sigma-Aldrich) was added to the media for 24 h to induce the expression of an shRNA against MYCN in IMR-5/75 cells and overexpress MYCN in SH-SY5Y/MYCN cells

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To investigate the potential synergy of two or more drugs in combination at reduced doses, the Bliss Independence model was used