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After NSAIDs or insulin overdose or cuprizone (a neurotoxin that induces multiple sclerosis like lesion in rat model) or large bowel resection, encephalopathies were attenuated along with gastrointestinal, liver and vascular injuries

-Synuclein and the BBB: dysregulation of major transporters Immunohistochemistry of the wall of leptomeningeal vessel in human brain tissues demonstrated intense staining of -synuclein in endothelial and smooth muscle cells [127]

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Standard (Evidence Strength: Grade A) Oral Medications Clinicians may prescribe pharmacologic pain management agents (e.g., urinary analgesics, acetaminophen, NSAIDs, opioid/non-opioid medications) after counseling patients on the risks and benefits