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Nature 484 , 514518 (2012)

& Sahl, H.-G

Furthermore, we believe that the brain network changes and alterations in neurotransmission that are characteristic of bipolar disorder disrupt brainbody signaling in ways that may in the future allow for novel therapeutic methodologies that reverse the autonomic, neuroendocrine, and immune systems that are characteristic of the disorder and that almost certainly contribute to the high degree of medical morbidity observed in bipolarity