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It is clear that the COX-2 inhibitors are safer, better tolerated, and equally efficacious, but many clinical issues need to be fully resolved

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3 Results 3.1 Impact of remogliflozin on liver function markers in TAA-intoxicated rats TAA administration significantly impaired liver function, as evidenced by a 350.9% increase in ALT and a 472.4% increase in AST, while albumin decreased by 67.4%, in contrast to the control group

ACTL6A impacts GSH de novo synthesis mainly by upregulating -glutamyl-cysteine synthesis To further assess the mechanism by which ACTL6A regulates GSH metabolism, we investigated the metabolic fate of U- 13 C glucose by liquid chromatography with mass spectrometry (LCMS), which produces -GC containing two 13 C atoms via GSH de novo synthesis pathway, GSH containing two 13 C atoms via GSH de novo synthesis or the SGOC pathway, or four 13 C atoms via both pathways (Fig