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A systematic review looking at the emerging evidence on the association between IrAEs and clinical outcomes highlighted the existence of a plausible direct proportionality of a therapeutic effect across ICI agents and solid tumours [47]

A convenience sample of children diagnosed with a precursor to hypermobile EDS at a tertiary hospital who were followed for three years found four factors that predicted disease severity and modestly predicted development of disability over time: multisystem involvement, pain, fatigue, and postural control

(4)(5) Opioid receptors : Further research indicates that DSIP might indirectly affect opioid receptors in the brain

2b, c and d) in relation to control-treated models