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Research shows that people who used semaglutide had lower vitamin B12 levels (they also had bariatric surgery before using semaglutide), and another study concluded that people with obesity had lower B12 levels

Axial Arthropathy Axial arthritis is also associated with IBD but is independent of IBD disease activity

However, the effectiveness of a topical cream is brought into question due to things like sweat and rubbing off on clothes, etc

Clinical studies have shown that individuals using Semaglutide for weight management can lose significant amounts of body weight, with some studies showing an average weight loss of around 1520% of total body weight