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doi: 10.3109/00365529609051994

The usual adult dosage is 1 ampoule daily for 5 days or as directed by a physician

Cominetti C, de Bortoli MC, Garrido AB Jr, Cozzolino SM

At the physiological phenotype level, CRISPRa has also been used to increase the transcription of obesity risk genes SIM1 and MC4R , and to successfully rescue haploinsufficient obesity in mouse modelswith the effects persisting up to 9 months post-treatment [80]