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3.4.1 Inflammatory Markers IF has been linked to reducing systemic inflammation, as indicated by lowered circulating levels of significant inflammatory markers, including C-reactive protein (CRP) and interleukin-6 (IL-6) [63, 64]

E3 ligases are the most diverse and functionally specialized components of the UPS and are responsible for substrate recognition and the final transfer of ubiquitin to target proteins

Since the liver is critical in manufacture and detoxification of hormones, this could explain a link between women suffering heavy periods and vitamin B12 deficiency and hormone imbalance

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