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A patient with gout has been shown in a broad range of studies to be at higher risk of coronary disease , and should have an evaluation appropriate to coronary risk (for example, lab testing for cholesterol and triglyceride level).3 It is important that damage to bone from gout be diagnosed, since documented damage is a clear indication for long-term therapy (see below)

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In summary, key aspects of body homeostasis, including the bidirectional functioning of the microbiota-gut-brain axis, rely on two parallel regulation systems, one purely nervous, the ANS, the other neuroendocrine, the HPA axis