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During Phase 1 detoxification, a family of enzymes known as Cytochrome P450 (CYP450) modifies toxins through oxidation

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Under rosiglitazone induction, the mRNA expression of adipogenic markersincluding leptin receptor (LEPR), peroxisome proliferator-activated receptor gamma (PPAR-), and lipoprotein lipase (LPL)was significantly upregulated (Khanmohammadi et al., 2014)