Kidney epithelial cell line HEK293 subclone HEK293A (human embryonic kidney cells transformed with sheared human adenovirus type 5 DNA) were obtained from Invitrogen
The transdermal composition of claim 2 wherein polymer is selected from one or more of polyethylene glycol, methacrylate copolymers (Eudragits), Acrylic copolymer, Polyster Film/copolymer of ethylene and vinyl acetate, Poly (Butyl methacrylate, methyl methacrylate), cellulose polymers (carboxymethylcellulose, ethyl cellulose, hydroxypropylmethylcellulose hydroxypropylcellulose), polyvinylpyrrolidone, polymer of acrylic acid crosslinked with allyl ethers of polyalcohols (carbomer / carbopol)
Adequate GSH maintains GPX4 in its reduced state, preventing oxidative inactivation, whereas GSH depletion leads to decreased GPX4 activity or even complete inactivation
[DOI] [PubMed] [Google Scholar] Danielli A