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Some concerns about a metabolite called TMAO (linked to cardiovascular risk) but the picture is complicated and context-dependent Nicotine on its own (not tobacco) does have real cognitive enhancing effects through acetylcholine receptor activation The delivery method is the problem, not the nicotine itself Gum or patches are a very different risk profile than cigarettes Ketogenic diet shifts the GABA to glutamate balance in the brain toward more inhibitory calming signaling That is part of why it works so well for epilepsy and possibly anxiety 03:15:20 Nattokinase