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However, it is banned by the World Anti-Doping Agency (WADA) for competitive athletes

While the more obvious route would be directly suppressing TNF, that might not be a good idea because of its important roles in fighting infections and other invaders, which is already a concern for current treatments, they say

Symptoms of vitamin B12 deficiency include: Anemia Intestinal disorders and weight loss Fatigue, weakness, lightheadedness Memory loss or confusion Depression or dementia Rapid heartbeat and respiration Mouth or tongue soreness or bleeding Excessive bruising Injections are the most effective means of administration of vitamin B12 since they do not depend on the body's ability to absorb the substance through the gastrointestinal tract

Subgroup analyses evaluated four key factors: administration route efficacy, daily dosage, age group and clinical conditions that may affect vitamin B12 metabolism (e.g., underlying pathology)