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These findings highlight that the lack of consistent findings across studies is a major factor underlying the weak ROSs assigned to these exposureoutcome associations

One 2018 National Academy of Medicine report found that there was some evidence that e-cigarette use increases the frequency and amount of cigarette smoking in the future

In fact, CS is one of the most established major risk factors for many oral diseases, including periodontal disease, dental caries, aphthous ulcers, primary Sjgrens syndrome and peri-implantitis [14,15,16]

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