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The euchromatin is characterized by an open state and is amenable to transcription, while the heterochromatin is characterized by a compact DNA-protein structure that cannot be transcribed (Jenuwein and Allis, 2001)

Chandra J, Gilbreath J, Freireich EJ, Kliche KO, Andreeff M , Keating M, McConkey DJ

Key Cellular and Molecular Events Fibroblasts, keratinocytes and macrophages Fibroblasts play a vital role in repairing the wound because they are involved in producing collagen, fibronectin and proteoglycan which constitute the extracellular matrix

A 2025 Nature Communications paper mapped the binding to the disordered transactivation domain of p53, adding structural detail to how FOXO4-DRI engages its target