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FOXO4-DRI is a D-retro-inverso peptide, meaning its amino acid sequence is reversed and uses mirror-image D-amino acids, making it resistant to enzymatic degradation while maintaining binding activity

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We think that the [neurons influence] on intervertebral disc degeneration is not only limited to the occurrence of pain, but also intervertebral disc degeneration itself, said Ximing Xu, professor in the Department of Orthopedic Surgery in Changzheng Hospital, and co-lead author of the study

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