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Studies using rat brain mitochondria have shown that safinamide exhibits 5,000 times greater selectivity for MAO-B over MAO-A, compared to the more modest selectivity ratios of 127 times for selegiline and 103 times for rasagiline [82]

On the contrary, anti-TPO antibodies were slightly increased, without reaching statistical significance

Oral forms have been studied but results are variable

143 While some of these agents have demonstrated isolated positive findings, the overall evidence base remains insufficient, with most studies being limited by small sample sizes, methodological variability, or lack of replication