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This link between cysteine-oxidative catabolism-derived pyruvate and cancer has been described in pancreatic cancer 73 and non-small lung cancer cells, 69 although additional studies that focus on other cancer types are required to strengthen this association

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The limited results indicated no measurable adverse acute effects on hepatic, renal, cardiac, or thyroid biomarkers, suggesting basic short-term tolerability

Cell aggregate models or spheroid models consist of endothelial cells, astrocytes, and pericytes, which are able to self-organize into spherical structures with astrocyte core, surrounded by pericytes and covered with endothelial cells (Urich et al., 2013)