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The biodegradable drug carrier comprises ABA-type or BAB-type triblock copolymers, or mixtures thereof, wherein the A-blocks are relatively hydrophobic and comprise biodegradable polyesters or poly(orthoester)s, and the B-blocks are relatively hydrophilic and comprise polyethylene glycol (PEG), said copolymers having a hydrophobic content of between 50.1 to 83% by weight and a hydrophilic content of between 17 to 49.9% by weight, and an overall block copolymer molecular weight of between 2000 and 8000 Daltons

By inhibiting NNMT, 5-Amino-1MQ prevents the methylation of nicotinamide, allowing more substrate to enter the NAD+ salvage pathway

The glutathione redox cycle plays a key role in the reduction of intracellular hydroperoxides

Similarly, Xie et al