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For ROS-related issues, propranolol has been previously studied for its effectiveness in inhibiting xanthine oxidase and superoxide 16

Although many clinical trials have reported that vitamins C and E have beneficial effects on alleviating the symptoms of oxidative stress-related diseases such as cardiovascular diseases and cancers, the same number of studies have reported no or very limited effects of supplemental vitamins C and E

In contrast, the apoptosis inhibitor Z-VAD-FMK exerted only a modest effect, and the necroptosis inhibitor Necrostatin-1 showed minimal protection (Fig

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