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Peak plasma concentrations occur 8 to 72 hours post-injection, and steady-state concentrations are achieved after approximately 4 weeks of consistent weekly dosing

That point is supported with the extensive gene expression analysis

Post-injection, the needle should not be immediately withdrawn but rather left in situ within the peritoneal cavity for an additional duration to effectively seal the puncture site and prevent medicinal leakage, ensuring the medication disperses effectively with the organs movements

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