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Contact a healthcare provider or emergency services if you experience: Severe difficulty breathing or shortness of breath Loss of consciousness or extreme sedation Severe allergic reactions such as rash, swelling, or difficulty swallowing Sudden confusion or inability to wake up Prompt treatment can prevent serious complications

This represents direct evidence of the mechanism at the cellular level, though its translation to clinical longevity outcomes in humans continues to be studied

Importantly, the IGF-1R is also critical for the increased expression of StAR under FSH stimulation, which is required for mitochondrial transport of cholesterol for the first step of sex steroid synthesis, pregnenolone production (60)

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