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As mental illness is associated with higher levels of nicotine dependence it is possible that mental illness could be a factor in failing to quit smoking [21, 22]

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Neither the Flemish nobleman and physician John Baptista van Helmont nor the English doctor Thomas Willis mentioned the use of smoking in their accounts of asthma, even though both writers acknowledged that the accumulation of phlegm in the lungs constituted a pivotal feature of the disease in many patients