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Intriguingly, there is a strong indication that nicotine, a major component in cigarette smoke, significantly contributes to smoke-induced immunosuppression by attenuating NK cell activity, T-cell proliferation, macrophage antigen processing activity, and dendritic cell number 42,43,44,45,46,47,48,49,50

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Consumer preferences in the industry are gradually shifting toward flavored cigarettes, particularly among younger, urban, and health-conscious smokers

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