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3 Impact of tobacco smoke on enzymatic drug metabolism Cigarette smoke is a complex mixture of chemicals, including toxic and carcinogenic substances such as polycyclic aromatic hydrocarbons (PAHs), ammonia, aromatic amines, phenols, carbonyls, hydrocyanic acid, and N-nitrosamines ( Nicotine and PAHs are among the most well-documented compounds found in tobacco products

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The initial general reaction to tobacco was positive, with people thinking it alleviated hunger, acted as a relaxant and even had the capabilities to cure cancer