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Additionally, BH 4 may prevent CoQ 10 depletion by alleviating oxidative stress and by promoting its synthesis by converting phenylalanine into tyrosine, which can further be converted into a CoQ 10 precursor (4HB), thereby reducing lipid peroxidation levels via CoQ 10

Patients can often resume their daily activities shortly after treatment

This supports its use in TM and highlights its potential for development as an anti-HTN drug (274)

The discovery of MPTP-induced PD led to major breakthroughs that indicated how the downstream effects of mitochondrial damagesuch as reduced adenosine triphosphate (ATP) production and increased reactive oxygen species (ROS)drive PD progression