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Recent research indicates that endothelial dysfunction is a key factor in the advancement of diabetic cardiomyopathy (Knapp et al., 2019)

The copper coordination chemistry of GHK-Cu enables controlled cellular copper delivery while preventing the formation of reactive oxygen species characteristic of free copper toxicity, with the peptide's binding affinity (log K = 16.1) positioning it perfectly within the physiological copper transport hierarchy to facilitate controlled metal transfer to enzymatic targets including lysyl oxidase (essential for collagen cross-linking) and superoxide dismutase (critical for antioxidant defense)

& Mochizuki, H

Janky R, Varga V, Saransaari P, and Oja SS