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Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) ME/CFS is defined as persistent or relapsing fatigue for at least six months, which is not resolved by rest, and causes a substantial reduction in the Activity of Daily Living (ADL) 206

Cost considerations Brand-name injectable tirzepatide (Mounjaro, Zepbound) costs over $1,000 per month without insurance

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Supplements worth considering during the higher dose phases include a quality multivitamin (to cover micronutrient gaps from reduced food intake), vitamin D (often depleted during significant weight loss), B vitamins for energy metabolism, and magnesium for muscle function and sleep quality