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Loren Pickart in 1973, GHK-Cu was discovered when Pickart observed that albumin from young donors (age 20-25) could stimulate aged liver tissue to synthesize proteins at a youthful rate, and the active factor was traced to this small copper peptide

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The effects of ANP on lipolysis are more relevant to primates than rodents, as rodents express over 100 times the level of the clearance receptor NP clearance receptor (NPCR), which mitigates the effect of ANP on lipolysis (112, 113)

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