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For the identification of druggable targets, we considered three classes of enzymes: tier-1 targets, tier-2 targets, and other enzymes. Tier-1 targets correspond to enzymes whose knockout impedes viral replication while having a minimal impact on the simulated cellular viability

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Berberine can alleviate cognitive function of Alzheimers disease mice via reducing the hyperphosphorylation of tau and promoting the autophagy clearance of tau (Chen Y

AnkB-deficient animals have sinus bradycardia, a prolonged QT interval, and other myocardial electrical phenotype changes, promoting myocardial mechanical remodelling as well as premature death, which is related to the low expression of -catenin in the intercalated disc and high expression in the cytoplasm caused by the loss of AnkB