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This enzymatic action depletes the available intracellular pool of nicotinamide, directly limiting the synthesis of nicotinamide adenine dinucleotide (NAD+)

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For keeping up the treatment, injections are often given monthly

Phase 3 Standard Cagrilintide Dose Based on Phase 2 findings, the standard cagrilintide dose for Phase 3 trials was established at: 2.4 mg administered subcutaneously once weekly This dose represents the optimal balance between: Efficacy : Substantial weight loss and metabolic improvements Safety : Manageable side effect profile Tolerability : Acceptable patient adherence rates The REDEFINE 1 trial, which evaluated cagrilintide in combination with semaglutide (CagriSema), used this 2.4 mg dose and demonstrated remarkable results