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LactMed notes that several studies on its effects on lactation are unable to offer valid conclusions because of their lack of blinding, randomization, and placebo control.48 However, there's at least one randomized control trial of particular relevance here because it used a combination of goat's rue and a silymarin phytosome

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Toxicity of intermediates was higher than that of the parent molecule (assessment with the use of Microtox bioassay)