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Dihexa demonstrates potent anti-neuroinflammatory effects critical for neuroprotection

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To account for the continuing degeneration and atrophy in later stages, in the face of waning adaptive inflammation as the disease progresses, it has been proposed that the inflammation becomes trapped behind the bloodbrain barrier, continuing to damage the CNS, but now being inaccessible to peripherally-administered immunosuppressants

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Its ability to cross the bloodbrain barrier in laboratory models, combined with a relatively long plasma half-life compared to other small neuropeptides, has contributed to its enduring relevance in neurochemistry research

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