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Discussion The ability of bacterial populations or subpopulations of persister cells to survive high concentrations of bactericidal antibiotics for extended periods, despite lacking resistance mutations, is probably a major factor contributing to treatment failure 2,22,24,46,47,48,49
As stress may incur an excess of glucocorticoids or reductions in neurotrophin levels which are thought to be associated with decreased astrocytic density and impaired astrocytic function, it may, in turn, lead to disruption of glutamatergic system and subsequent neurotoxicity The insults: Infection, chronic stress, trauma, drugs, etc
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