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After two years of treatment, an increase in bone mineral density and a decrease in urine calcium concentration was seen with both medication regimens, but the group treated with alendronate plus hydrochlorothiazide had more improvement than the group treated with alendronate alone (Arrabal-Polo, Arias-Santiago 2013)

As the false lumen expands, it can lead to severe complications such as aortic valve insufficiency, pericardial tamponade, or even rupture of the aorta

NAPQI is rapidly detoxified by glutathione (GSH), but in situations of GSH deficiency, excess NAPQI reacts with cysteine residues in proteins, causing cell death and toxicity in the liver

2012;30(28):3499506 (Epub 2012/09/06)