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Although lifestyle changes are the first line of treatment for obesity, even the most rigorous lifestyle changes typically only produce a 510% weight loss and maintaining weight over time is difficult due to compensatory physiological processes that increase appetite and decrease energy expenditure [134]

Rather than supplying growth hormone from outside, it works upstreamsignaling the pituitary gland to do the job itself

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Freezing can cause the benzyl alcohol to separate from the water, and the freeze-thaw cycle can potentially create micro-fractures in the glass vial, compromising its sterility