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During the oxidation phase, accumulated ROS (such as hydrogen peroxide HO and superoxide anion O) in the cell can directly react with GSH in a non-enzymatic manner, or, under the catalysis of glutathione peroxidase (GPX), promote the oxidative coupling of two GSH molecules to form one molecule of GSSG, while releasing two protons (H) and two electrons (e)

Marks JL, Hofstetter WL, Correa AM, Mehran RJ, Rice DCKomaki R, Wei X, Allen P, Roth JA, Swisher S, Rice DC , Walsh GL, Fossella FV, Erasmus JJ, Cox JD

It is marketed as a drug to alleviate neuropathic pain, and there are suggestions that it may help with cognitive and mood disorders

Fate of the hypertrophic chondrocyte: Microenvironmental perspectives on apoptosis and survival in the epiphyseal growth plate