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J Biol Chem 291:2283022840 Fan Y, He JJ (2016) HIV-1 Tat induces unfolded protein response and endoplasmic reticulum stress in astrocytes and causes neurotoxicity through Glial Fibrillary Acidic Protein (GFAP) activation and aggregation

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If cessation pharmacology eventually proves to have been a complete sham upon smokers it does not follow that all involved were charlatans, or necessarily motivated by financial conflicts of interest, or knew it was a sham