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117 A double-blind, randomized, placebo-controlled study involving 737 adults over age 65 with subclinical hypothyroidism found that levothyroxine treatment at a starting dose of 50 mcg, adjusted according to TSH levels, did not improve hypothyroid symptoms, tiredness, or quality of life measures

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Injectable/IV glutathione for whitening is not an approved use and has prompted regulatory warnings over serious adverse effects, so the risk-benefit balance for cosmetic injection is considered unfavorable

Results Randomized group assignments and timeline are shown in Fig