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Kupffer cells hyperplasia and narrowed hepatic sinusoids were also observed (grade I)

Furthermore, Pycnogenol was shown to prevent the release and activity of destructive enzymes (metalloproteinases 1, 2 and 9), which break down tissue proteins such as collagen and elastin

doi: 10.3389/fnut.2021.784354 Received 27 September 2021 Accepted 27 October 2021 Published 22 November 2021 Volume 8 - 2021 Edited by Annalisa Terranegra, Sidra Medicine, Qatar Reviewed by Guoyuan Qi, University of Arizona, United States